{"id":152142,"date":"2022-06-22T14:03:11","date_gmt":"2022-06-22T13:03:11","guid":{"rendered":"https:\/\/radioljubuski.ba\/?p=152142"},"modified":"2022-06-22T14:03:12","modified_gmt":"2022-06-22T13:03:12","slug":"revolucionaran-medicinski-pomak-znanstvenici-izlijecili-i-regenerirali-srce-osteceno-srcanim-udarom","status":"publish","type":"post","link":"https:\/\/radioljubuski.ba\/index.php\/2022\/06\/22\/revolucionaran-medicinski-pomak-znanstvenici-izlijecili-i-regenerirali-srce-osteceno-srcanim-udarom\/","title":{"rendered":"Revolucionaran medicinski pomak: Znanstvenici izlije\u010dili i regenerirali srce o\u0161te\u0107eno sr\u010danim udarom"},"content":{"rendered":"\n

Znanstvenici su razvili novu tehniku \u200b\u200bkoja mo\u017ee popraviti, pa \u010dak i regenerirati stanice sr\u010danog mi\u0161i\u0107a nakon sr\u010danog udara ili infarkta miokarda. Iako je do sada testirana samo na mi\u0161evima, ako jednako djeluje i na ljudima, potencijalno bi ta tehnika mogla biti spasonosna terapija za ljude koji su pretrpjeli sr\u010dani udar.<\/p>\n\n\n\n

Tehnika koristi sinteti\u010dku ribonukleinsku kiselinu (mRNK), koja stvara ‘nacrt’ DNK sekvenci koje tijelo zatim koristi za izgradnju proteina koji formiraju i reguliraju na\u0161e stanice. Pode\u0161avanjem mRNK, znanstvenici mogu dati razli\u010dite upute za razli\u010dite biolo\u0161ke procese.<\/p>\n\n\n\n

Tako ure\u0111ene upute promi\u010du replikaciju stanica sr\u010danog mi\u0161i\u0107a (kardiomiocita) putem dva takozvana mutirana transkripcijska faktora, Stemina i YAP5SA. U osnovi, ideja je da stanice sr\u010danog mi\u0161i\u0107a, koje imaju vrlo malu sposobnost regeneracije, djeluju vi\u0161e kao mati\u010dne stanice, koje tijelo mo\u017ee pretvoriti u razne druge vrste specijaliziranih stanica.<\/p>\n\n\n\n

Nitko nije uspio to u\u010diniti u ovoj mjeri i mislimo da bi to moglo postati mogu\u0107a terapija za ljude, ka\u017ee biolog Robert Schwartz sa Sveu\u010dili\u0161ta Houston u Teksasu i jedan od autora nove studije objavljene u znanstvenom \u010dasopisu Journal of Cardiovascular Aging.<\/p>\n\n\n\n

Manje od jedan posto odraslih sr\u010danih mi\u0161i\u0107nih stanica mo\u017ee se regenerirati, jer kardiomiociti koje imamo kad umremo uglavnom su isti oni koje smo imali od prvog mjeseca \u017eivota, a to zna\u010di da sr\u010dani udari i sr\u010dane bolesti mogu ostaviti srce u trajno krhkom stanju.<\/p>\n\n\n\n

U eksperimentima u posudama za kulturu tkiva i na \u017eivim mi\u0161evima, pokazalo se da Stemin uklju\u010duje svojstva sli\u010dna mati\u010dnim stanicama u kardiomiocitima, dok je YAP5SA poticao rast i replikaciju organa. Znanstvenici su proces opisali kao revolucionaran na tom polju medicine.<\/p>\n\n\n\n

In vivo studija koja je uklju\u010divala \u017eive mi\u0161eve zahva\u0107ene o\u0161te\u0107enim srcem pokazala je da se jezgre miocita repliciraju najmanje 15 puta u 24 sata nakon injekcija mutiranih faktora transkripcije, Stemina i YAP5SA.<\/p>\n\n\n\n

Kada su oba transkripcijska faktora ubrizgana u srca odraslih mi\u0161eva s infarktom, rezultati su bili zapanjuju\u0107i. Laboratorij je otkrio da su se sr\u010dani miociti brzo umno\u017eavali unutar jednog dana, dok su srca tijekom sljede\u0107eg mjeseca bila popravljena na skoro normalnu sr\u010danu pumpnu funkciju s malim o\u017eiljcima, ka\u017ee Schwartz.<\/p>\n\n\n\n

Sinteti\u010dka mRNK dodana stanicama nestala je za nekoliko dana, ba\u0161 kao \u0161to to \u010dini mRNK proizvedena u na\u0161im tijelima, ka\u017eu znanstvenici. To novoj tehnici daje prednost u odnosu na procese genske terapije, koji se ne mogu lako zaustaviti ili ukloniti nakon \u0161to su u tijeku.<\/p>\n\n\n\n

Jo\u0161 uvijek ostaje za vidjeti mo\u017ee li se pristup uspje\u0161no prevesti na ljude, a bit \u0107e potrebno jo\u0161 mnogo godina istra\u017eivanja kako bi se ovo u\u0161lo u djelotvornu terapiju, no znanstveni tim koji je proveo ovo najnovije istra\u017eivanje uvjeren je u pozitivan ishod.<\/p>\n\n\n\n

Ovo je velika studija regeneracije srca, posebno s obzirom na pametnu strategiju kori\u0161tenja mRNK za isporuku Stemina i YAP5SA, ka\u017ee biolog Siyu Xiao sa Sveu\u010dili\u0161ta u Houstonu.<\/p>\n\n\n\n

Izvor:pogled.ba<\/p>\n","protected":false},"excerpt":{"rendered":"

Znanstvenici su razvili novu tehniku \u200b\u200bkoja mo\u017ee popraviti, pa \u010dak i regenerirati stanice sr\u010danog mi\u0161i\u0107a nakon sr\u010danog udara ili infarkta miokarda. Iako je do sada testirana samo na mi\u0161evima, ako jednako djeluje i na ljudima, potencijalno bi ta tehnika mogla biti spasonosna terapija za ljude koji su pretrpjeli sr\u010dani udar. Tehnika koristi sinteti\u010dku ribonukleinsku kiselinu […]<\/p>\n","protected":false},"author":2,"featured_media":152143,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"h5ap_radio_sources":[],"footnotes":""},"categories":[1],"tags":[],"class_list":["post-152142","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bihiregija"],"yoast_head":"\nRevolucionaran medicinski pomak: Znanstvenici izlije\u010dili i regenerirali srce o\u0161te\u0107eno sr\u010danim udarom - RADIO LJUBU\u0160KI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/radioljubuski.ba\/index.php\/2022\/06\/22\/revolucionaran-medicinski-pomak-znanstvenici-izlijecili-i-regenerirali-srce-osteceno-srcanim-udarom\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Revolucionaran medicinski pomak: Znanstvenici izlije\u010dili i regenerirali srce o\u0161te\u0107eno sr\u010danim udarom - RADIO LJUBU\u0160KI\" \/>\n<meta property=\"og:description\" content=\"Znanstvenici su razvili novu tehniku \u200b\u200bkoja mo\u017ee popraviti, pa \u010dak i regenerirati stanice sr\u010danog mi\u0161i\u0107a nakon sr\u010danog udara ili infarkta miokarda. Iako je do sada testirana samo na mi\u0161evima, ako jednako djeluje i na ljudima, potencijalno bi ta tehnika mogla biti spasonosna terapija za ljude koji su pretrpjeli sr\u010dani udar. 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