{"id":55765,"date":"2021-08-21T09:45:56","date_gmt":"2021-08-21T08:45:56","guid":{"rendered":"https:\/\/radioljubuski.ba\/?p=55765"},"modified":"2021-08-21T09:45:58","modified_gmt":"2021-08-21T08:45:58","slug":"svi-pricaju-o-trecoj-dozi-cjepiva-a-kada-ce-zatrebati-i-hrvatskim-gradanima-odgovara-imunolog-trobonjaca-pojavio-se-delta-plus-soj-evo-zasto-je-on-jako-opasan","status":"publish","type":"post","link":"https:\/\/radioljubuski.ba\/index.php\/2021\/08\/21\/svi-pricaju-o-trecoj-dozi-cjepiva-a-kada-ce-zatrebati-i-hrvatskim-gradanima-odgovara-imunolog-trobonjaca-pojavio-se-delta-plus-soj-evo-zasto-je-on-jako-opasan\/","title":{"rendered":"Svi pri\u010daju o tre\u0107oj dozi cjepiva, a kada \u0107e zatrebati i hrvatskim gra\u0111anima odgovara imunolog Trobonja\u010da. \u2018Pojavio se delta-plus soj, evo za\u0161to je on jako opasan\u2018"},"content":{"rendered":"\n

Nakon \u0161to je ameri\u010dka administracija objavila da \u0107e njihovim gra\u0111anima u rujnu biti ponu\u0111ena tre\u0107a, tzv. ‘booster’ doza cjepiva, predsjednik SAD-a Joe Biden<\/strong> potvrdio je kako \u0107e se on i prva dama Jill Biden<\/strong> odmah cijepiti. Porastom broja novozara\u017eenih sve vi\u0161e i drugih zemalja razmi\u0161lja o tre\u0107oj dozi, a od rujna s ‘boosterom’ kre\u0107u i Njema\u010dka, Velika Britanija i Francuska.<\/p>\n\n\n\n

Kod nas odluke o tre\u0107oj dozi nema, \u0161to ne \u010dudi jer je procijepljenost i s dvije doze preniska. Do sad je cijepljeno 50 posto odraslog stanovni\u0161tva, \u0161to je jako daleko od \u017eeljenih i potrebnih 80 posto.<\/p>\n\n\n\n

\u201eCijepljenje s tre\u0107om dozom u Hrvatskoj ne bi u \u010detvrtom valu rasteretilo bolni\u010dki sustav jer su i dalje prvi na udaru COVID-a, necijepljeni kojih imamo puno. Ne razumijem osobe koje se ne \u017eele cijepiti. Ne mo\u017eete okrenuti glavu i misliti da \u0107e vas virus zaobi\u0107i jer ne\u0107e. Te osobe ne mogu se toliko izolirati niti primjenjivati protuepidemijske mjere da bi ih ovaj visokozarazni i brzo\u0161ire\u0107i virus zaobi\u0161ao. Inficirat \u0107e se kad tad – ka\u017ee nam ugledni virusni imunolog prof. dr. Zlatko Trobonja\u010da<\/strong> sa Medicinskog fakulteta Sveu\u010dili\u0161ta u Rijeci.<\/p>\n\n\n\n

\u0160to se ti\u010de tre\u0107e doze njome bi, smatra na\u0161 sugovornik u rujnu ili listopadu, trebalo cijepiti  najrizi\u010dnije imunokrompomitirane kategorije stanovni\u0161tva.<\/p>\n\n\n\n

Zdravoj populaciji dr. Trobonja\u010da savjetuje da se cijepe tre\u0107om dozom tek onda kada se razvije cjepivo za delta-soj, na kojem upravo radi Pfizer.<\/p>\n\n\n\n

\"image\"\/<\/figure>\n\n\n\n

Isti\u010de kako prilikom odluke o tre\u0107oj dozi treba voditi ra\u010duna o dvije stvari: o padu antitijela \u0161to se zbiva odre\u0111enim protokom vremena nakon cijepljenja, te o pojavi novih sojeva na koje postoje\u0107a cjepiva slabije reagiraju.<\/p>\n\n\n\n

Najnovije britansko istra\u017eivanje sugerira kako je sada\u0161nje Pfizerovo cjepivo u\u010dinkovitije protiv delta-varijante koronavirusa od AstraZenecina, ali za\u0161tita koju pru\u017ea s vremenom se smanjuje. Osoba koja je prije mjesec dana primila drugu dozu Pfizera 90 posto je za\u0161ti\u0107enija protiv delte od necijepljene osobe. Dva mjeseca nakon primanja druge doze razlika se smanjuje na 85 posto, a nakon tri mjeseca na 78 posto. Cjepivo AstraZenece, prema istra\u017eivanju, pru\u017ea za\u0161titu od 67 posto nakon jednog mjeseca, 65 posto nakon dva i 61 posto nakon tri mjeseca. Nakon \u010detiri do pet mjeseci razina za\u0161tite koju daju Pfizer i AstraZeneca ujedna\u010dava se.<\/p>\n\n\n\n

\"image\"\/<\/figure>\n\n\n\n

– Koncentracija antitijela nakon cijepljenja raste otprilike \u010detrdesetak dana nakon primanja druge doze. Imunosni mehanizmi se pove\u0107avaju cijelo to vrijeme, no onda po\u010dinju stagnirati i kroz idu\u0107ih desetak mjeseci koncentracija antitijela pada. Kad koncentracija antitijela zna\u010dajno padne mo\u017eemo se zaraziti. E, sad je pitanje kad se to mo\u017ee dogoditi nakon cijepljenja? Kod odre\u0111ene skupine ljudi ta antitijela u zna\u010dajnoj mjeri nestaju nakon desetak mjeseci ili godine dana, a kod drugih kasnije \u2013 obja\u0161njava profesor te napominje kako imunokompromitirane osobe razvijaju slabiju imunost.<\/p>\n\n\n\n

– Oni razvijaju oko 40-ak posto slabiju imunost po cijepljenju i svakako bi ih trebali dodatno za\u0161titi i cijepiti tre\u0107om dozom i to osam do 12 mjeseci nakon primljene druge doze. Radi se o ljudima koji su na kemoterapiji ili o onima koji su nedavno transplantirali organe i primaju imunosupresivnu terapiju, odnosno ako imaju autoimune bolesti ili kroni\u010dne upalne bolesti koje zahtijevaju imunomodeliraju\u0107u terapiju. Njih treba dodatno cijepiti bez obzira na to kolika je op\u0107a procijepljenost u zemlji.<\/p>\n\n\n\n

Drugi faktor o kojem ovisi davanje tre\u0107e doze su mutacije virusa. Mi smo cijepljeni protiv originalnog soja, a u me\u0111uvremenu se pojavljuje novi soj od kojeg nas cjepivo \u0161titi samo djelomi\u010dno – veli.<\/p>\n\n\n\n

Sad kad imamo i delta-plus soj, pitamo profesora Trobonja\u010du koliko je opasniji od delte?  <\/p>\n\n\n\n

\u00a0– Delta plus ima na proteinu \u0161iljka mutaciju K417N koju delta nema i moglo bi se dogoditi da ‘izgura’ deltu. Opasan je jer je od delte zadr\u017eao zaraznost, a uz to posti\u017ee i imunoevanzivnost. Delta-plus, naime, ima mutaciju u najva\u017enijem dijelu proteina \u0161iljka, a to je domena S proteina \u0161iljka, koja vezuje receptor, a znamo da je ona ne samo va\u017ena za virus, nego je i imunodominantna, odnosno na\u0161 imunosni sustav ba\u0161 protiv tog dijela proteina \u0161iljka stvara najvi\u0161e antitijela. U principu, ako se u tom dijelu virus promijeni, antitijela koja smo prethodno stvorili vi\u0161e se ne mogu povezivati s tim dijelom proteina \u0161iljka. Ta mutacija vodi u imunoevazivanost virusa tj. izbjegava imunost koja je postignuta cijepljenjem ili preboljenjem nekog drugog soja, tuma\u010di nam. \u00a0<\/p>\n\n\n\n

\"image\"\/<\/figure>\n\n\n\n

Ovaj smo tjedan imali i slu\u010daj Domu za starije Tre\u0161njevka gdje je bilo pozitivno 22 korisnika, koji su se cijepili prije gotovo osam mjeseci.<\/p>\n\n\n\n

–  Da, ali svi oni imaju bla\u017ee simptome. Upravo je to potvrda da cjepivo djeluje jer ono mo\u017eda ne\u0107e sprije\u010diti infekciju, ali ho\u0107e razvijanje te\u017ee plu\u0107ne ili sistemske bolesti \u0161to Covid vrlo \u010desto izaziva kod starije populacije, navodi imunolog.<\/p>\n\n\n\n

Poznat mu je i primjer iz Belgije gdje je sedmero \u0161ti\u0107enika Doma za umirovljenike preminulo nakon zaraze kolumbijskom varijantom koronavirusa unato\u010d tome \u0161to su bili u potpunosti cijepljeni.<\/p>\n\n\n\n

– Kolumbijski soj je kombinacija nekoliko mutacija i o\u010dito je imunoevazivan, odnosno izbjegava imunost postignutu cijepljenjem. Kolumbijski soj je prisutan u Europi, no koliko vidimo ne \u0161iri se brzo kako se \u010dinilo u po\u010detku. Mislim da \u0107e ga potisnuti delta soj koji je sad dominantan.     <\/p>\n\n\n\n

PI\u0160E <\/strong>ANITA BELAK KRILE<\/a>\/slobodnadalmacija.hr<\/p>\n","protected":false},"excerpt":{"rendered":"

Nakon \u0161to je ameri\u010dka administracija objavila da \u0107e njihovim gra\u0111anima u rujnu biti ponu\u0111ena tre\u0107a, tzv. ‘booster’ doza cjepiva, predsjednik SAD-a Joe Biden potvrdio je kako \u0107e se on i prva dama Jill Biden odmah cijepiti. Porastom broja novozara\u017eenih sve vi\u0161e i drugih zemalja razmi\u0161lja o tre\u0107oj dozi, a od rujna s ‘boosterom’ kre\u0107u i Njema\u010dka, Velika Britanija i […]<\/p>\n","protected":false},"author":2,"featured_media":55766,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"h5ap_radio_sources":[],"footnotes":""},"categories":[1],"tags":[],"class_list":["post-55765","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bihiregija"],"yoast_head":"\nSvi pri\u010daju o tre\u0107oj dozi cjepiva, a kada \u0107e zatrebati i hrvatskim gra\u0111anima odgovara imunolog Trobonja\u010da. \u2018Pojavio se delta-plus soj, evo za\u0161to je on jako opasan\u2018 - RADIO LJUBU\u0160KI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/radioljubuski.ba\/index.php\/2021\/08\/21\/svi-pricaju-o-trecoj-dozi-cjepiva-a-kada-ce-zatrebati-i-hrvatskim-gradanima-odgovara-imunolog-trobonjaca-pojavio-se-delta-plus-soj-evo-zasto-je-on-jako-opasan\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Svi pri\u010daju o tre\u0107oj dozi cjepiva, a kada \u0107e zatrebati i hrvatskim gra\u0111anima odgovara imunolog Trobonja\u010da. \u2018Pojavio se delta-plus soj, evo za\u0161to je on jako opasan\u2018 - RADIO LJUBU\u0160KI\" \/>\n<meta property=\"og:description\" content=\"Nakon \u0161to je ameri\u010dka administracija objavila da \u0107e njihovim gra\u0111anima u rujnu biti ponu\u0111ena tre\u0107a, tzv. ‘booster’ doza cjepiva, predsjednik SAD-a Joe Biden potvrdio je kako \u0107e se on i prva dama Jill Biden odmah cijepiti. 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