{"id":67348,"date":"2021-09-24T01:11:52","date_gmt":"2021-09-24T00:11:52","guid":{"rendered":"https:\/\/radioljubuski.ba\/?p=67348"},"modified":"2021-09-24T01:13:30","modified_gmt":"2021-09-24T00:13:30","slug":"antitijela-koja-proizvode-ljame-imaju-znacajnog-potencijala-u-lijecenju-covida","status":"publish","type":"post","link":"https:\/\/radioljubuski.ba\/index.php\/2021\/09\/24\/antitijela-koja-proizvode-ljame-imaju-znacajnog-potencijala-u-lijecenju-covida\/","title":{"rendered":"Antitijela koja proizvode ljame imaju “zna\u010dajnog potencijala” u lije\u010denju covida"},"content":{"rendered":"\n

Si\u0107u\u0161na antitijela koja proizvode ju\u017enoameri\u010dke ljame mogla bi predstavljati novo oru\u017eje u borbi protiv koronavirusa, pokazuje istra\u017eivanje.<\/strong><\/p>\n\n\n\n

Znanstvenici s Instituta Rosalind Franklin otkrili su da nanotijela – manji, jednostavni oblik antitijela koja stvaraju ljame i deve-mogu u obliku spreja za nos u\u010dinkovito ciljati virus Sars-CoV-2 koji uzrokuje Covid-19.

Kratki lanci molekula, koji se mogu proizvesti u velikim koli\u010dinama u laboratoriju, zna\u010dajno su smanjili simptome Covida-19 kada su se davali zara\u017eenim \u017eivotinjskim modelima, prema studiji.

Nanotijela su se \u010dvrsto vezala za virus neutraliziraju\u0107i ga u laboratoriju, te bi mogla pru\u017eiti jeftiniju i jednostavniju alternativu ljudskim antitijelima uzetim pacijentima oporavljenim od Covida-19.

Ljudska protutijela kori\u0161tena su za ozbiljne slu\u010dajeve tijekom pandemije, ali obi\u010dno ih je potrebno dati u infuziji u bolnici.

– Iako je ovo istra\u017eivanje jo\u0161 u ranoj fazi, otvara zna\u010dajne mogu\u0107nosti za kori\u0161tenje u\u010dinkovitih tretmana covida-19 nanotijelima, rekao je profesor Miles Carroll<\/strong>, zamjenik ravnatelja Nacionalne slu\u017ebe za zarazne bolesti pri Engleskom javnom zdravstvu (PHE).

– Ovo su me\u0111u naju\u010dinkovitijim sredstvima za neutraliziranje Sars-CoV-2 koje smo do sada testirali na PHE-u, rekao je Carroll.

– Vjerujemo da jedinstvena struktura i snaga nanotijela doprinose njihovom zna\u010dajnom potencijalu i za prevenciju i za lije\u010denje Covid-19 i radujemo se zajedni\u010dkom radu na putu prema klini\u010dkim studijama, naglasio je.

Profesor Ray Owens<\/strong>, voditelj proizvodnje proteina na Institutu Rosalind Franklin i vode\u0107i autor istra\u017eivanja, rekao je: “Nanotijela imaju niz prednosti u odnosu na ljudska antitijela”.

– Jeftiniji su za proizvodnju i mogu se unijeti izravno u di\u0161ne putove putem raspr\u0161iva\u010da ili spreja za nos, pa se mogu sami primijeniti kod ku\u0107e, umjesto da se njihovo uno\u0161enje obavlja uz pomo\u0107 igala, govori.

– Ovo bi moglo biti korisno u smislu jednostavne upotrebe za pacijenata, ali tako\u0111er dovodi lijek izravno na mjesto infekcije u di\u0161nom traktu, nagla\u0161ava Owens.

Istra\u017eiva\u010di su uspjeli generirati nanotijela ubrizgavanjem dijela proteina \u0161iljaka u ljamu po imenu Fifi, koja je dio pogona za proizvodnju antitijela na Sveu\u010dili\u0161tu u Readingu.

Protein \u0161iljaka nalazi se s vanjske strane virusa i odgovoran je za vezanje na ljudske stanice kako bi ih virus mogao zaraziti. Iako injekcije nisu u\u010dinile Fifi bolesnom, one su pokrenule njezin imuni sustav na borbu protiv virusnog proteina stvaranjem nanotijela protiv njega.

Od ljame je uzet mali uzorak krvi i istra\u017eiva\u010di su uspjeli izlu\u010diti \u010detiri nanotijela sposobna za vezanje na virus. Nanotijela su zatim spojena u lance od po tri kako bi se pove\u0107ala njihova sposobnost vezanja za virus. Oni su zatim proizvedeni u laboratorijskim stanicama.

Studija je otkrila da su tri lanca nanotijela uspjela neutralizirati i izvorne varijante virusa Covid-19 i alfa varijantu.

\u010cetvrti lanac nanotijela uspio je neutralizirati beta varijantu virusa. Kad su hr\u010dcima zara\u017eenim virusom dali jedan od lanaca nanotijela, \u017eivotinje su pokazale zna\u010dajno smanjenje simptoma bolesti.

Hr\u010dci koji su primili tretman s nanotijelima imali su nakon sedam dana manje virusa u plu\u0107ima i di\u0161nim putovima od nelije\u010denih \u017eivotinja.

Znanstvenici ka\u017eu da su rezultati prvi korak prema razvoju nove vrste lije\u010denja Covid-19, koja bi se mogla pokazati neprocjenjivom kako se pandemija nastavlja.

Profesor James Naismith<\/strong>, direktor Instituta Rosalind Franklin, koji je pomogao u vo\u0111enju istra\u017eivanja, rekao je: “Imati lijekove koji mogu lije\u010diti virus i dalje \u0107e biti vrlo va\u017eno, posebno jer se cijeli svijet ne cijepi istom brzinom i ostaje rizik od pojave novih varijanti sposobnih zaobi\u0107i u\u010dinak cjepiva. “

Istra\u017eiva\u010dki tim, koji je uklju\u010divao znanstvenike sa Sveu\u010dili\u0161ta Liverpool, Sveu\u010dili\u0161ta Oxford i PHE, sada se nadaju dobiti sredstva za pripremu klini\u010dkih studija na ljudima.

Rezultati istra\u017eivanja objavljeni su u \u010dasopisu Nature Communication.<\/p>\n\n\n\n

Izvor:hrt.hr<\/p>\n","protected":false},"excerpt":{"rendered":"

Si\u0107u\u0161na antitijela koja proizvode ju\u017enoameri\u010dke ljame mogla bi predstavljati novo oru\u017eje u borbi protiv koronavirusa, pokazuje istra\u017eivanje. Znanstvenici s Instituta Rosalind Franklin otkrili su da nanotijela – manji, jednostavni oblik antitijela koja stvaraju ljame i deve-mogu u obliku spreja za nos u\u010dinkovito ciljati virus Sars-CoV-2 koji uzrokuje Covid-19. Kratki lanci molekula, koji se mogu proizvesti […]<\/p>\n","protected":false},"author":2,"featured_media":67349,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"h5ap_radio_sources":[],"footnotes":""},"categories":[1],"tags":[],"class_list":["post-67348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bihiregija"],"yoast_head":"\nAntitijela koja proizvode ljame imaju "zna\u010dajnog potencijala" u lije\u010denju covida - RADIO LJUBU\u0160KI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/radioljubuski.ba\/index.php\/2021\/09\/24\/antitijela-koja-proizvode-ljame-imaju-znacajnog-potencijala-u-lijecenju-covida\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antitijela koja proizvode ljame imaju "zna\u010dajnog potencijala" u lije\u010denju covida - RADIO LJUBU\u0160KI\" \/>\n<meta property=\"og:description\" content=\"Si\u0107u\u0161na antitijela koja proizvode ju\u017enoameri\u010dke ljame mogla bi predstavljati novo oru\u017eje u borbi protiv koronavirusa, pokazuje istra\u017eivanje. Znanstvenici s Instituta Rosalind Franklin otkrili su da nanotijela – manji, jednostavni oblik antitijela koja stvaraju ljame i deve-mogu u obliku spreja za nos u\u010dinkovito ciljati virus Sars-CoV-2 koji uzrokuje Covid-19. 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