{"id":76946,"date":"2021-10-17T02:35:30","date_gmt":"2021-10-17T01:35:30","guid":{"rendered":"https:\/\/radioljubuski.ba\/?p=76946"},"modified":"2021-10-17T02:35:31","modified_gmt":"2021-10-17T01:35:31","slug":"znanstvenici-na-tragu-lijeka-protiv-borelioze-za-bolest-koju-prenose-krpelji-jos-ne-postoji-cjepivo-a-moze-postati-kronicna-pazite-na-ove-simptome","status":"publish","type":"post","link":"https:\/\/radioljubuski.ba\/index.php\/2021\/10\/17\/znanstvenici-na-tragu-lijeka-protiv-borelioze-za-bolest-koju-prenose-krpelji-jos-ne-postoji-cjepivo-a-moze-postati-kronicna-pazite-na-ove-simptome\/","title":{"rendered":"Znanstvenici na tragu lijeka protiv borelioze? Za bolest koju prenose krpelji jo\u0161 ne postoji cjepivo, a mo\u017ee postati kroni\u010dna; Pazite na ove simptome"},"content":{"rendered":"\n

– Imamo dobre \u0161anse uskoro iskorijeniti boreliozu – smatra Kim Lewis<\/strong>, profesorica biologije i direktorica Centra za otkrivanje antimikrobnih sredstava (Antimicrobial Discovery Center) na Sveu\u010dili\u0161tu Northeastern u Bostonu. Razlog optimizmu je (ponovno) otkri\u0107e kemikalije koja je kobna za bakteriju koja izaziva bolest, ali bezopasna za \u017eivotinje, prenosi DW<\/a>.<\/p>\n\n\n\n

Boreliozu (ili Lajmsku bolest) uzrokuje bakterija Borrelia burgdorferi koja se nastanjuje u malim glodavcima poput \u0161takora ili mi\u0161eva, ali i u plemenitoj divlja\u010di, poput srna. Te \u017eivotinje pritom ne pokazuju nikakve simptome bolesti. Krpelji djeluju kao prijenosnici: one se inficiraju kada si\u0161u krv tih \u017eivotinja, a onda prenose bakterije na nove doma\u0107ine – poput ljudi.<\/p>\n\n\n\n

JESAM LI ZARA\u017dEN?<\/h2>\n\n\n\n

Jedan od naj\u010de\u0161\u0107ih znakova zaraze boreliozom je tipi\u010dna kru\u017ena upala ko\u017ee koja se stvara oko ugriza krpelja i prstenasto se \u0161iri. To takozvano lutaju\u0107e crvenilo (Erythema migrans) javlja se kod 80% do 90% pacijenata.<\/p>\n\n\n\n

No postoje i drugi simptomi, sli\u010dni gripi: umor, bolovi u zglobovima, bolovi u mi\u0161i\u0107ima, povi\u0161ena temperatura ili no\u0107no znojenje.<\/p>\n\n\n\n

KAKO SE ZA\u0160TITITI?<\/h2>\n\n\n\n

Prevencija borelioze jo\u0161 nije mogu\u0107a. Ujede krpelja treba izbjegavati od samog po\u010detka. Prilikom \u0161etnji po livadama i \u0161umama trebali nositi dugu odje\u0107u, posebno na nogama. Dobre su visoke \u010darape, pogotovo ako se navuku preko hla\u010da.<\/p>\n\n\n\n

Krpelji su vidljiviji na odje\u0107i svijetlih boja. Sprejevi protiv krpelja zadr\u017eavaju krpelje barem na ograni\u010deno vrijeme, no nisu svi jednako pouzdani.<\/p>\n\n\n\n

Kod ku\u0107e treba temeljito provjeriti ima li krpelja. Ako se neki uhvatio, treba ga odmah ukloniti. \u0160to prije to bolje!<\/p>\n\n\n\n

KAKO SE LIJE\u010cI BORELIOZA?<\/h2>\n\n\n\n

U ranim fazama borelioza se mo\u017ee lije\u010diti antibioticima. Ako se borelioza bolest ne lije\u010di, ona postaje kroni\u010dna i stalno se vra\u0107a.<\/p>\n\n\n\n

U SAD -u i Kanadi postojalo je cjepivo pod nazivom LYMErix. 1998. je odobreno za cijepljenje pacijenata s visokim rizikom, ali 2002. firma GlaxoSmithKline je prekinula proizvodnju zbog lo\u0161e prodaje. Danas se cijepljenje protiv koristi u veterinarstvu – na primjer za pse. Ali ono se mora osvje\u017eavati svake godine.<\/p>\n\n\n\n

Obe\u0107avaju\u0107e vijesti stigle su u rujnu ove godine: farmaceutske tvrtke Valnea i Pfizer objavile su prve pozitivne rezultate probne faze mogu\u0107eg cjepiva VLA15, no ono je jo\u0161 u fazi istra\u017eivanja i razvoja.<\/p>\n\n\n\n

NOVA NADA<\/h2>\n\n\n\n

Druga\u010diji pristup ima tim predvo\u0111en Kim Lewis sa Sveu\u010dili\u0161ta Northeastern. U novoj je studiji predstavljen spoj zvan Hygromycn A. On je potpuno bezopasan za \u017eivotinje i ima samo mali u\u010dinak na ve\u0107inu bakterija, osim na bakterije spiroheta. Za njih je to kobno. A upravo toj vrsti pripada Borrelia burgdorferii.<\/p>\n\n\n\n

Hygromycn A je antimikrobno sredstvo prona\u0111eno u tlu. Aktivni sastojak izvorno je otkriven 1953. godine. Me\u0111utim, tada su ga znanstvenici odbacili kao neu\u010dinkovit. Vjerojatno je bio preslab protiv normalnih patogena, ali Lewis ga smatra “iznimno u\u010dinkovitim” protiv spiroheta.<\/p>\n\n\n\n

Njen tim je testirao Hygromycn A za lije\u010denje borelioze kod mi\u0161eva i otkrio da je, kako ka\u017ee Lewis, “vrlo dobar u uklanjanju bolesti”. Nakon pet dana lije\u010denja Hygromycnom A, infekcija je izlije\u010dena u sli\u010dnom omjeru kao u kontrolnoj skupini koja je primala antibiotik ceftriakson. Prednost: Hygromycin A djeluje vrlo specifi\u010dno protiv Borrelia burgdorferi, dok Ceftriaxone djeluje protiv mnogih razli\u010ditih bakterija, \u0161to onda poti\u010de razvijanje otpornosti bakterija na antibiotike.<\/p>\n\n\n\n

Znanstvenici su ve\u0107 licencirali aktivni sastojak Flightpathu, biotehnolo\u0161koj tvrtki specijaliziranoj za boreliozu, kako bi proveli studije i unaprijedili proizvodnju ovog lijeka.<\/p>\n\n\n\n

– Nadam se da \u0107e se razvoj nastaviti u pozitivnom pravcu i da \u0107emo dobiti prvi lijek za lije\u010denje borelioze – rekla je Lewis.<\/p>\n\n\n\n

No planovi su jo\u0161 ambiciozniji: znanstveni tim okupljen oko Kim Lewis je pokazao da hranjenje mi\u0161eva mamcem inficiranim Hygromycnom mo\u017ee sasvim ukloniti bakteriju Borrelia burgdorferi. Na\u010delno bi se postavljanjem takvog mamca mogla iskorijeniti borelioza u \u010ditavim regijama.<\/p>\n\n\n\n

Ova ideja nije posve nova. Ve\u0107 ranije je provo\u0111eno terensko ispitivanje s mamcima doksiciklina, i ono je bilo uspje\u0161no. Me\u0111utim, \u0161iroka upotreba sredstva u tu svrhu nije po\u017eeljna jer bi mogla dovesti do razvoja brojnih mikroba rezistentnih na antibiotike. Nasuprot tome, studije tima Kim Lewis upu\u0107uju na to da je bakteriji B. burgdorferi izuzetno te\u0161ko razviti rezistenciju na Hygromycn.<\/p>\n\n\n\n

Prvo terensko ispitivanje bi trebalo po\u010deti sljede\u0107e ljeto. A osim toga Kim Lewis istra\u017euje mo\u017ee li Hygromycn A lije\u010diti druge bolesti uzrokovane spirohetama, poput sifilisa, uzrokovanog bakterijom Treponema pallidum.<\/p>\n\n\n\n

PI\u0160E <\/strong>PSD<\/p>\n","protected":false},"excerpt":{"rendered":"

– Imamo dobre \u0161anse uskoro iskorijeniti boreliozu – smatra Kim Lewis, profesorica biologije i direktorica Centra za otkrivanje antimikrobnih sredstava (Antimicrobial Discovery Center) na Sveu\u010dili\u0161tu Northeastern u Bostonu. Razlog optimizmu je (ponovno) otkri\u0107e kemikalije koja je kobna za bakteriju koja izaziva bolest, ali bezopasna za \u017eivotinje, prenosi DW. Boreliozu (ili Lajmsku bolest) uzrokuje bakterija Borrelia burgdorferi koja […]<\/p>\n","protected":false},"author":2,"featured_media":76947,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"h5ap_radio_sources":[],"footnotes":""},"categories":[1],"tags":[],"class_list":["post-76946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bihiregija"],"yoast_head":"\nZnanstvenici na tragu lijeka protiv borelioze? 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